Kyoji Horie

This study investigates how dysregulated flow responses in endothelial cells contribute to Sturge-Weber syndrome pathogenesis using cellular models and omics analyses.

The paper identifies complex on-target vector insertions in CRISPR-edited mouse cells using long-read sequencing, revealing that these insertions can escape standard PCR-based quality control.

This study compares CRISPR/Cas9 methods for deleting a 2.5-Mb gene cluster in mouse embryonic stem cells, finding higher success rates with targeting vectors.

This study shows that disrupting Smarce1 in mouse embryonic stem cells reduces nucleosome stability and impairs differentiation by altering chromatin structure.

This study shows that inhibiting N-myristoyltransferase (Nmt) promotes naive pluripotency in both mouse and human pluripotent stem cells.