Aromatic Microbial Metabolite Hippuric Acid Potentiates Pro-Inflammatory Responses in Macrophages through TLR-MyD88 Signaling and Lipid Remodeling
Gauri Mirji, Sajad Ahmad Bhat, Mohamed E. El Sayed, Sarah Kim Reiser, Siva Pushpa Gavara, Ying Ye, Taito Miyamoto, Qin Liu, Aaron R. Goldman, Andrew V. Kossenkov, Nan Zhang, Rahul Suresh Shinde
This study identifies hippuric acid as a microbial metabolite that enhances pro-inflammatory responses in macrophages via TLR-MyD88 signaling and lipid remodeling, with implications for infection and inflammation.
bioRxiv · May 19, 2025 · PreprintImmunology