IFI16/AIM2 inflammasomes control Gal-9 and PVR in myeloid cells from PWH and their targeting improves immunotherapy against HIV-1
Marta Calvet‐Mirabent, Ilya Tsukalov, Ildefonso Sánchez‐Cerrillo, Jesus Pino-Platas, Paul Nicholas Holmes-Anton, María Agudo-Lera, Olga Popova, Raquel González, Lucio Jesus García-Fraile, José Antonio Lebrón-Romero, Manuel López‐López, Sergio Serrano-Villar, Santiago Moreno, Pilar López‐Cornejo, Francisco Sánchez‐Madrid, , Enrique Martín‐Gayo
The paper shows that inhibiting IFI16 and AIM2 in myeloid cells from HIV-1 patients reduces Gal-9 and PVR, enhancing CD8+ T-cell responses against HIV-1.
bioRxiv · Jan 28, 2026 · PreprintImmunology