Author

Martijn Zwama

The Institute of Scientific and Industrial Research, The University of OsakaORCID 0000-0001-9081-382XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Kunihiko NishinoiD· 2 shared Diogo Figueiredo· 1 shared Mitsuru HattoriiD· 1 shared Takeharu NagaiiD· 1 shared Tetsuichi WazawaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

Kunihiko NishinoORCID

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2 papers

Recent·Most cited

BiochemistryScientific ReportsPeer-reviewedSep 17, 2026

Fusion of a non-specific DNA-binding domain enhances Cas12a trans-cleavage for robust nucleic-acid diagnostics

Diogo Figueiredo, Mitsuru Hattori, Tetsuichi Wazawa…·Takeharu Nagai

This paper enhances Cas12a's trans-cleavage activity by fusing Sso7d, improving sensitivity and kinetics for nucleic-acid detection.

DOI 10.1038/s41598-026-71516-z

DNA methylationproteomics

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Molecular BiologyAntimicrobial Agents and ChemotherapyPeer-reviewedMar 21, 2022

Proximal binding pocket Arg717 substitutions in Escherichia coli AcrB cause clinically relevant divergencies in resistance profiles

Martijn Zwama, Kunihiko Nishino

This paper investigates Arg717 substitutions in Escherichia coli AcrB, finding they increase resistance to macrolides and fluoroquinolones while decreasing resistance to novobiocin and cloxacillin.

15 citations

E. colistatistical model

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