Fusion of a non-specific DNA-binding domain enhances Cas12a trans-cleavage for robust nucleic-acid diagnostics
Diogo Figueiredo, Mitsuru Hattori, Tetsuichi Wazawa…·Takeharu Nagai
This paper enhances Cas12a's trans-cleavage activity by fusing Sso7d, improving sensitivity and kinetics for nucleic-acid detection.