Author

Roy Straver

Utrecht UniversityORCID 0000-0002-8031-1735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Assay:Hi-C· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Jeroen de RidderiD· 3 shared Carlo VermeuleniD· 2 shared Alessio MarcozziiD· 1 shared Amin AllahyariD· 1 shared Benjamin D. RowlandiD· 1 shared Boudewijn M.T. BurgeringiD· 1 shared Brian J.P. HuntlyiD· 1 shared Britta A. M. BouwmaniD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioinformatics

Jeroen de RidderORCID

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Author profile →

3 papers

Recent·Most cited

Direct detection of 8-oxo-dG using nanopore sequencing

Marc Pagès-Gallego, Daan M. K. van Soest, Nicolle J.M. Besselink, Roy Straver, Janneke P. Keijer, Carlo Vermeulen, Alessio Marcozzi, Markus J. van Roosmalen, Ruben van Boxtel, Boudewijn M.T. Burgering, Tobias B. Dansen, Jeroen de Ridder

The paper develops a method to directly detect 8-oxo-dG using nanopore sequencing by creating synthetic DNA with context variability and training deep learning models.

Nature Communications · Jun 5, 2025Peer-reviewedBioinformatics

Mutational synergy with CREBBP loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse model

Nathalie Sakakini, Roy Straver, Dhoyazan Azazi, Sarah J. Horton, Ryan Asby, Simon E. Richardson, Pedro Madrigal, Elizabeth J. Soilleux, Rachael J. M. Bashford-Rogers, Jeroen de Ridder, Brian J.P. Huntly

bioRxiv · Mar 25, 2024 · PreprintCancer Biology

Locus-Specific Enhancer Hubs And Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

Amin Allahyar, Carlo Vermeulen, Britta A. M. Bouwman, Peter H.L. Krijger, Marjon J.A.M. Verstegen, Geert Geeven, Melissa van Kranenburg, Mark Pieterse, Roy Straver, Judith H.I. Haarhuis, Kees Jalink, Hans Teunissen, Ivo Renkens, Wigard P. Kloosterman, Benjamin D. Rowland, , Wouter L. de Laat

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.

Nature Genetics · Jul 6, 2018Peer-reviewedGenetics