Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes
Xi Dawn Chen, Zeyu Chen, George Wythes, Yifan Zhang, Benno C. Orr, Gary Sun, Yu-Kai Chao, Andrea Navarro Torres, Ka Thao, Mounica Vallurupalli, Jing Sun, Mehdi Borji, Emre Tkacik, Haiqi Chen, B Bernstein, Fei Chen
The paper develops a tool for continuous, long-range, targeted diversification of endogenous mammalian genomes and uses it to explore the function of genetic variants in both coding and non-coding regions.
Science · Oct 10, 2024Peer-reviewedGenetics