Author
Emre Tkacik
Harvard UniversityORCID 0000-0001-8274-1248Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 19 mutual co-author links6 papers
Recent·Most cited
- BiochemistrybioRxivPreprint
RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor
Sayan Chakraborty, Jie Jiang, Javier Viñals…·Michael J. Eck
The paper investigates MEK inhibitor selectivity across RAF isoforms and develops a covalent ARAF-MEK inhibitor with improved potency.
- BiochemistrybioRxivPreprint
In vitro reconstitutions suggest a general model for paradoxical activation of ARAF, BRAF, and CRAF by diverse RAF inhibitor types that does not rely on negative allostery.
Emre Tkacik, Dong Man Jang, Kayla Boxer…·Michael J. Eck
This study shows that RAF inhibitors paradoxically activate ARAF, BRAF, and CRAF through dimerization, not negative allostery, by using biochemical assays and mass photometry.
DOI 10.64898/2025.12.15.694443 - BiochemistrybioRxivPreprint
Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF complexes
Emre Tkacik, Dong Man Jang, Kayla Boxer…·Michael J. Eck
This study compares the potency of thirteen RAF inhibitors against ARAF, BRAF, and CRAF isoforms, revealing differences in inhibitor selectivity and mechanism.
- GeneticsSciencePeer-reviewed
Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes
Xi Dawn Chen, Zeyu Chen, George Wythes…·Fei Chen
The paper develops a tool for continuous, long-range, targeted diversification of endogenous mammalian genomes and uses it to explore the function of genetic variants in both coding and non-coding regions.
45 citationstop 2% - Molecular BiologybioRxivPreprint
Molecular mechanisms for activation of the 26S proteasome
Dong Hoon Lee, Yanan Zhu, Louis Colson…·Ying Lu
The paper investigates how ZFAND5 activates the 26S proteasome by inducing conformational changes that enhance substrate degradation.
DOI 10.1101/2023.05.09.540094