Puneet Opal

This paper shows that neurofilament accumulation in GAN disrupts autophagy through impaired organelle distribution and sequestration of 14-3-3, affecting TFEB localization.

This study identifies RNA-binding protein interactions of gigaxonin, a protein mutated in Giant Axonal Neuropathy, revealing potential mechanisms linking its dysfunction to neurodegeneration.

The paper identifies a JNK-dependent signaling pathway in Bergmann glia that drives inflammation in spinocerebellar ataxia, showing that inhibiting this pathway improves disease symptoms.