Author

Shuichi Hoshika

Firebird Biomolecular Sciences (United States)ORCID 0000-0001-9128-1183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Steven A. BenneriD· 2 shared Adele WilliamsoniD· 1 shared Alexandra Perry· 1 shared Caitlin Walters-Freke· 1 shared Cen CheniD· 1 shared David A. RuslingiD· 1 shared Dylan Justice· 1 shared Michael Brazzill· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Steven A. BennerORCID

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2 papers

Recent·Most cited

Cell BiologyNucleic Acids ResearchPeer-reviewedOct 13, 2026

Sequence-Specific Targeting of GC-Rich Gene Loci by Parallel Triplex-Forming Oligonucleotides Containing a Modified Nucleobase

Ruolin Ma, Michael Brazzill, Dylan Justice…·David A. Rusling

This paper demonstrates that Z-modified TFOs can repress endogenous gene expression by forming stable triplexes at GC-rich regulatory elements.

DOI 10.1093/nar/gkag998

DNA methylationexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintJul 1, 2026

DNA Ligases Discriminate Between Natural and Non-Natural Base Pairs

Caitlin Walters-Freke, Shuichi Hoshika, Alexandra Perry…·Adele Williamson

The paper investigates how DNA ligases handle non-canonical base pairs in hachimoji DNA, finding that consecutive non-canonical bases at the 3-end reduce ligation efficiency.

DOI 10.64898/2026.06.30.734188

DNA methylationexperimental assay

𝕏 PostBluesky