Xu Shi

Genetic Mapping of All Human Paralog Pairs to Characterize Synthetic Lethality and Buffering

This study screens all human paralog pairs to identify synthetic lethal interactions and finds that their strength depends on shared protein interaction networks and cellular context.

INSIGHT: In Silico Drug Screening Platform using Interpretable Deep Learning Network

The paper introduces INSIGHT, a deep learning framework that predicts drug response using multiomics data and drug molecular structure, outperforming existing methods and enabling biological interpretation.

The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models

The paper introduces the EN-TEx resource, which provides personal epigenomes and variant-impact models across multiple tissues, revealing allele-specific loci and their associations with GWAS loci.

ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

ChIP-BIT2 detects weak transcription factor binding events by integrating ChIP-seq sample and input data using a Bayesian approach.