Daniel Verduzco

This study screens all human paralog pairs to identify synthetic lethal interactions and finds that their strength depends on shared protein interaction networks and cellular context.

A genome-wide CRISPR screen and genetic analysis identify TNRC18 as a novel regulator of IL-1β production and a risk factor for inflammatory diseases.

This study optimizes genomewide CRISPR screens using AsCas12a and multi-guide arrays, finding that three guides per gene construct provide optimal performance.