Author

Zhiguang Wu

Roslin InstituteORCID 0000-0001-9131-730XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:chicken / avian· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Adam BaliciD· 3 shared Lonneke VerveldeiD· 3 shared David Arthur HumeiD· 2 shared Laura GlendinningiD· 2 shared Mike J. McGrewiD· 2 shared Alewo Idoko-AkohiD· 1 shared Androniki PsifidiiD· 1 shared Anum Ali AhmadiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

Adam BalicORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

ImmunologyThe Journal of ImmunologyPeer-reviewedJun 1, 2026

CSF1R-dependent macrophages control B cell development and function in the chicken immune system.

Zhiguang Wu, Rakhi Harne, Alewo Idoko-Akoh…·Adam Balic

This study identifies CSF1R-dependent macrophage subpopulations in chickens and shows their critical role in B cell development and function.

1 citation

chicken / avianscRNA-seq

𝕏 PostBluesky

ImmunologyeLifePeer-reviewedOct 16, 2025

Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds.

Dominique Meunier, Ricardo Corona-Torres, Kay Boulton…·David Arthur Hume

This study investigates the role of IL10 in avian mucosal immunity by generating IL10-deficient chickens, showing altered microbiome composition and enhanced pathogen clearance with increased inflammation.

6 citations

chicken / avianproteomics

𝕏 PostBluesky

MicrobiologyMicrobial GenomicsPeer-reviewedSep 2, 2024

Infectious bronchitis virus vaccination, but not the presence of XCR1, is correlated with large differences in chicken caecal microbiota

Laura Glendinning, Zhiguang Wu, Lonneke Vervelde…·Adam Balic

This study compares the caecal microbiota of XCR1 knockout chickens with and without IBV vaccination, finding that vaccination, not XCR1 absence, significantly alters microbiota composition.

2 citations

chicken / avianmetagenomics

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ImmunologybioRxivPreprintApr 3, 2018

Characterisation of subpopulations of chicken mononuclear phagocytes that express TIM4 and the macrophage colony-stimulating factor receptor (CSF1R)

Tuanjun Hu, Zhiguang wu, Stephen J. Bush…·Pete Kaiser

This study identifies TIM4-expressing mononuclear phagocytes in chickens, distinguishing phagocytic Kupffer cells from non-phagocytic DC-like cells using CSF1R reporters.

DOI 10.1101/294504

chicken / avianbulk RNA-seq

𝕏 PostBluesky