Roman Kurt Thomas

This study identifies a CD8+ T cell molecular signature specific to small cell lung cancer, showing its prognostic value and potential for immunotherapy.

This study benchmarks preprocessing strategies for single-cell transformer models and finds that simple log-transformed counts outperform complex methods, leading to a more efficient foundation model.

This study identifies NMD inhibition as a therapeutic strategy for SCLC by enhancing immunogenicity and improving immunotherapy efficacy through increased neoantigen presentation.

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.