Jian Ping Hu

This study uses symmetry analysis and ancestral sequence reconstruction to uncover the symmetric translocation pathway and activity determinants of ZIP metal transporters.

The paper functionally screens ZIP8 variants to identify pathogenic mutations and trafficking defects using a combined experimental and computational approach.

This study investigates the role of an N-terminal amphipathic helix in Nramp transporters, showing it regulates conformational dynamics and metal ion transport.

The paper investigates two LarA-like enzymes lacking a catalytic histidine residue, solving their structures and revealing a novel octameric assembly and active site residues involved in carbohydrate metabolism.

The paper analyzes naturally occurring missense mutations in human manganese transporters, comparing computational predictions with structural models to identify discrepancies and improve variant prioritization.

This paper identifies the LxL motif in ZIP4 as an atypical dileucine motif that mediates zinc-dependent endocytosis via AP2 and clathrin.

This study reports three high-resolution structures of a broad-spectrum LarA enzyme, revealing substrate binding mode and residues critical for substrate recognition and catalysis.

This study modifies key residues in ZIP8 to alter its metal transport activity and substrate spectrum, identifying variants with enhanced activity and expanded substrate preferences.

This study investigates the mechanism of metal substrate translocation in the ZIP transporter BbZIP using structural, biochemical, and computational methods, revealing unique conformational changes and transport dynamics.

This paper determines the turnover number of human ZIP4 using stable zinc isotopes and ICP-MS, finding it ranges from 0.08 to 0.2 s-1.