BiochemistryNature SynthesisPeer-reviewed
In-brain construction of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry
Seiji Sakamoto, Kazuki Shiraiwa, Mengchu Wang…·Itaru Hamachi
The paper develops a method to modify receptor proteins in the living mouse brain with fluorescent probes using ligand-directed and click chemistry, enabling high-resolution mapping of matrix metalloproteinase-9 activity near AMPARs.
6 citations