Seiji Sakamoto

This paper introduces tmPhoxID, a method to label the cytoplasmic side of transmembrane proteins using singlet oxygen, and demonstrates its application in identifying intracellular interactomes of specific receptors in the mouse brain.

This study develops semisynthetic biosensors to quantitatively map synaptic zinc dynamics in the mouse brain with synapse-level resolution.

The paper develops a method to modify receptor proteins in the living mouse brain with fluorescent probes using ligand-directed and click chemistry, enabling high-resolution mapping of matrix metalloproteinase-9 activity near AMPARs.

This paper introduces PhoxID, a light-activated proximity labeling method to study receptor interactomes in live mice with minute-order temporal resolution.

The paper introduces FixEL, a method to trap and image small molecules in brain tissue, enabling visualization of their distribution and dynamics.