Author

Nicola Ivan Lorè

IRCCS Ospedale San RaffaeleORCID 0000-0001-9159-1632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

Federico Di MarcoiD· 2 shared Stefano de PretisiD· 2 shared A. Vianello· 1 shared Alex GraudenziiD· 1 shared Anna GriegoiD· 1 shared Beatrice Antinori· 1 shared Daniela Maria Cirillo· 1 shared Daniela María CirilloiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBioinformatics

Federico Di MarcoORCID

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Author profile →

3 papers

Recent·Most cited

PatHoST: weakly supervised reconstruction of pathogen spatial distributions from host transcriptomes

Federico Di Marco, Francesca De Nicola, Gaia Saldarini, Daniela Maria Cirillo, Nicola Ivan Lorè, Alex Graudenzi, Stefano de Pretis

PatHoST reconstructs pathogen spatial distributions from host transcriptomes using weakly supervised learning, showing improved detection in both experimental and human SARS-CoV-2 data.

bioRxiv · Oct 30, 2026 · PreprintBioinformatics

Chronic mycobacteria infection triggers macrophage senescence

Edoardo Scarpa, Doriana Oliveri, Giorgia Moschetti, Anna Griego, A. Vianello, Diego Rondelli, Beatrice Antinori, Gabriele Marchello, Philina Santarelli, Manuel Albanese, Silvia Franzè, Gianluca Cidonio, Lara Manganaro, Nicola Ivan Lorè, Loris Rizzello

This study shows that chronic Mycobacterium abscessus infection causes macrophage senescence, leading to pro-inflammatory cytokine secretion and secondary senescence in neighboring cells.

bioRxiv · Nov 5, 2024 · PreprintMicrobiology

Dual host-bacterial gene expression to study pathogenesis and the regulation of virulence factors in tissue during respiratory infections

Federico Di Marco, Francesca Nicola, Francesca Giannese, Fabio Saliu, Giovanni Tonon, Stefano de Pretis, Daniela María Cirillo, Nicola Ivan Lorè

The paper demonstrates the use of dual host-bacterial gene expression analysis in FFPE tissues to study pathogenesis and virulence factor regulation during respiratory infections.

Communications Biology · Oct 9, 2024Peer-reviewedMicrobiology