Manuel Albanese

Optimizing CRISPR/Cas9 genome editing in primary human hematopoietic cells to advance studies into HIV biology

This study develops a CRISPR/Cas9 platform for editing primary human HSPCs to investigate HIV host factors and their impact on viral infection in vitro and in vivo.

A vesicle-based platform for high-efficiency, high-viability CRISPR/Cas9 knockout in primary human myeloid cells

This paper develops a vesicle-based CRISPR/Cas9 platform for efficient gene knockout in primary human myeloid cells, preserving viability and enabling downstream functional studies.

Chronic mycobacteria infection triggers macrophage senescence

This study shows that chronic Mycobacterium abscessus infection causes macrophage senescence, leading to pro-inflammatory cytokine secretion and secondary senescence in neighboring cells.