Loris Rizzello

A vesicle-based platform for high-efficiency, high-viability CRISPR/Cas9 knockout in primary human myeloid cells

This paper develops a vesicle-based CRISPR/Cas9 platform for efficient gene knockout in primary human myeloid cells, preserving viability and enabling downstream functional studies.

AD-HIES patients retain preTh17-cells that produce IL10 with opportunistic pathogens and induce IgE

The paper identifies IL-10-producing pre-Th17 cells in AD-HIES patients that respond to pathogens and support IgE production despite STAT3 mutations.

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

This study identifies a mechanical regulation pathway involving Src-FAK-AMPK-GBF1 that controls cargo sorting and secretion from the Golgi in response to substrate stiffness.

Chronic mycobacteria infection triggers macrophage senescence

This study shows that chronic Mycobacterium abscessus infection causes macrophage senescence, leading to pro-inflammatory cytokine secretion and secondary senescence in neighboring cells.

On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.

Targeting mononuclear phagocytes for eradicating intracellular parasites

This paper demonstrates the targeting and intracellular delivery of antibiotics to mononuclear phagocytes to eradicate intracellular parasites like Mycobacterium tuberculosis.