Author

Michael Spohn

Leibniz Institute of Virology (LIV)ORCID 0000-0001-9160-4157Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam T. GrundhoffiD· 2 shared Cédric FeschotteiD· 1 shared Christoph Schwarz· 1 shared Corinna Wülbeck· 1 shared Daniela IndenbirkeniD· 1 shared Eva TolosaiD· 1 shared Franziska M. EsmekiD· 1 shared Frauke Muecksch· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Adam T. GrundhoffORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 22, 2025

Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses

Martin V. Hamann, Lisa Brauckmann, Christoph Schwarz…·U. Schiefer Lange

This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.

DOI 10.1101/2025.09.22.676989

humanbulk RNA-seq

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Molecular BiologyPLoS PathogensPeer-reviewedAug 24, 2020

High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms

Manja Czech‐Sioli, Thomas Günther, Marlin Therre…·Nicole Fischer

This study identifies two MCPyV integration patterns in MCC and links them to NHEJ and MMBIR mechanisms, showing integration preference for open chromatin and viral promoter-driven oncogene expression.

44 citations

humanwhole-genome sequencing

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