Jonathan Edward Noonan

This study identifies mechanosensory pathways in monocytes exposed to pathological shear stress, revealing PKC and Piezo1 as key regulators of monocyte phenotype and function in calcific aortic valve disease.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.