Alex Bobik

Immune-Mediated Necrotic Cell Death Initiated by Stressed Cardiomyocytes is a Major Contributor to Cardiomyocyte Loss Following Myocardial Infarction

This study shows that cytotoxic γδ-T cells contribute to cardiomyocyte death after myocardial infarction, and targeting STING and type I interferon pathways reduces infarct size.

Autoimmune-like CD8⁺ T Cell Responses Drive Atherosclerotic Plaque Instability and Predict Cardiovascular Events

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

CD27+ γδ T Cells Drive Plaque Instability in Advanced Atherosclerosis: Targeting CXCR3 for Therapeutic Intervention

This study identifies CD27+ γδ T cells as key drivers of atherosclerotic plaque instability and shows that targeting CXCR3 with AMG487 improves plaque stability.

High-resolution transcriptomic profiling of the aortic cellular landscape during hypertension reveals novel drivers of vascular fibrosis

This study identifies a novel fibroblast subcluster, Fibro-Cthrc1, as a driver of aortic fibrosis in hypertension using scRNA-seq and validates its association with blood pressure in humans.