Karlheinz Peter

This study identifies mechanosensory pathways in monocytes exposed to pathological shear stress, revealing PKC and Piezo1 as key regulators of monocyte phenotype and function in calcific aortic valve disease.

This study shows that cytotoxic γδ-T cells contribute to cardiomyocyte death after myocardial infarction, and targeting STING and type I interferon pathways reduces infarct size.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This paper shows that targeting CD39 on endothelial cells prevents toxin-induced pulmonary hypertension in mice by multiple mechanisms including adenosine signaling and reducing inflammation.

This study identifies which Fcγ-receptors respond to CRP isoforms and shows that pCRP* is the main activator, differing from IgG-Fc interactions.

This paper develops an endothelial-targeted CD39 therapy for ischaemic stroke, showing reduced infarct size and improved BBB integrity when administered 3 hours post-ischaemia.

This paper develops Por-HDL-NPs for atherosclerosis theranostics, showing they reduce inflammation, promote cholesterol efflux, and visualize plaques via imaging.