Thomas Valerius

This paper develops a retargeted adenovirus system to produce IgA antibodies and CD47 blockers in tumors, enhancing innate immune responses and reducing tumor volume in mice.

This study evaluates BLN-driven cytotoxicity in β and γδ T-cell subsets, finding β T cells show superior cytotoxicity while γδ T cells exhibit stable effector-memory states and reduced susceptibility to activation-induced cell death.

This paper introduces a multifunctional fusion protein that enables efficient ex vivo expansion of NK cells from various sources and enhances their cytotoxic activity against tumor cells.

This paper evaluates a novel Fc-optimized antibody drug conjugate targeting CD7, showing potent anti-leukemia activity in preclinical T-ALL models.

This study evaluates the efficacy of CD38 and CD20 IgG1/IgA2 antibodies in mediating myeloid cell-mediated killing of B-ALL, showing enhanced activity with CD47/SIRPα blockade.