Zheng Zhang

The paper develops a pharmacokinetics-informed ODE model to extrapolate long-term transcriptomic responses to fenofibrate in rats, achieving high correlation and low error compared to baselines.

This study establishes a robust mDIA pipeline for EV proteomics, showing library-based DIA outperforms other methods and reveals IDH1 mutation effects on EV proteomes in cholangiocarcinoma.

The paper identifies D2HG and L2HG-induced O-2-hydroxyglutarylation with chiral specificity, revealing inhibitory effects on kinases MRCKA and SLK.