Lokesh Kumari Kadian

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophy

This study uses spatial transcriptomics to identify dysregulated transcriptional programs in multiple tissues of SMA mice, revealing non-neuronal pathological changes before motor neuron loss.

Covalent Inhibition of the Human Papillomavirus Type 16 E6 Protein Restores p53 and Suppresses HPV-Driven Tumorigenesis

The paper develops covalent inhibitors targeting HPV16 E6 protein, restoring p53 function and suppressing HPV-driven tumorigenesis in vitro and in vivo.