eSPLIT and iSWAP: CRISPR-Mediated Conditional Allele Engineering with Short Artificial Introns
Ankeeta Koirala, Kyle O'Connor, Samantha Bare, Max Toubin, Anastasiya Vydra, Annelise Cassidy, Amalee C. Strupp, Destinée B. Thomas, Hanying Chen, S. William Pelletier
The paper introduces eSPLIT and iSWAP, two methods for generating conditional alleles using short artificial introns, validated in human and mouse models.
bioRxiv · Dec 24, 2025 · PreprintGenomics