Author
Indiana University School of MedicineORCID 0000-0002-1127-0212Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
H. R. Sagara Wijeratne, Avery M. Runnebohm, Monica P. Barron…·Amber L. Mosley
The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.
Ankeeta Koirala, Kyle O'Connor, Samantha Bare…·S. William Pelletier
The paper introduces eSPLIT and iSWAP, two methods for generating conditional alleles using short artificial introns, validated in human and mouse models.
Anne Rietz, Lokesh Kumari Kadian, Ankeeta Koirala…·Elliot J. Androphy
The paper develops covalent inhibitors targeting HPV16 E6 protein, restoring p53 function and suppressing HPV-driven tumorigenesis in vitro and in vivo.
Avery M. Runnebohm, H. R. Sagara Wijeratne, Monica P. Barron…·Amber L. Mosley
The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.
Neil A. McCracken, Sarah A. Peck Justice, Whitney R. Smith-Kinnaman…·Amber L. Mosley
The paper uses proteomics and PISA analysis to study PERK-dependent changes in protein homeostasis during ER stress induced by tunicamycin.
Annelise Cassidy, Destinée B. Thomas, Emin Kuliyev…·S. William Pelletier
This paper describes a method to generate conditional alleles in mice using a short artificial intron and CRISPR-Cas9, showing successful insertion and efficient Cre-mediated deletion.