Elliot J. Androphy

This paper shows E2 activates the DNA damage response by displacing CIP2A from TOPBP1, promoting viral replication and cell proliferation through ATM activation and ATR inhibition.

This study uses spatial transcriptomics to identify dysregulated transcriptional programs in multiple tissues of SMA mice, revealing non-neuronal pathological changes before motor neuron loss.

The paper develops covalent inhibitors targeting HPV16 E6 protein, restoring p53 function and suppressing HPV-driven tumorigenesis in vitro and in vivo.

The paper describes a splicing modifier compound that creates a tunable mouse model of spinal muscular atrophy, showing efficacy in preventing and reversing SMA phenotypes with short-term treatment.