Anne Rietz

This study uses spatial transcriptomics to identify dysregulated transcriptional programs in multiple tissues of SMA mice, revealing non-neuronal pathological changes before motor neuron loss.

The paper develops covalent inhibitors targeting HPV16 E6 protein, restoring p53 function and suppressing HPV-driven tumorigenesis in vitro and in vivo.

The paper describes a splicing modifier compound that creates a tunable mouse model of spinal muscular atrophy, showing efficacy in preventing and reversing SMA phenotypes with short-term treatment.