Clarissa Scholes

This paper develops NanoCas, a compact CRISPR nuclease, and demonstrates its efficacy in editing non-liver tissues in non-human primates.

The paper integrates modeling and synthetic biology to show that transcriptional synergy depends on both kinetic regulation of the transcription cycle and TF binding.

The paper quantifies how shadow enhancers and their duplications combine transcriptional output in Drosophila embryos, showing variation in their computational behavior across expression patterns.

This study develops a quantitative framework to explore how transcription factors regulate gene expression through different kinetic steps of the transcription cycle, showing that combinatorial control can generate diverse computational outcomes without requiring co-localization.