Kelly M. Biette

The paper integrates modeling and synthetic biology to show that transcriptional synergy depends on both kinetic regulation of the transcription cycle and TF binding.

The paper quantifies how shadow enhancers and their duplications combine transcriptional output in Drosophila embryos, showing variation in their computational behavior across expression patterns.

The paper shows that Caudal counter-represses Hunchback to enable even-skipped stripe 2 expression in Drosophila embryos, challenging the traditional view of Hunchback as a direct activator.