Changxin Dong

This paper develops antimicrobial polyacrylamides using a cross-molecular machine learning pipeline trained on antimicrobial peptides, showing synergy with clinical drugs against E. coli biofilms.

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

This paper develops long-acting hydrogel-based depot formulations of semaglutide and tirzepatide that maintain drug levels for over 6 weeks in a rat model, showing similar efficacy to daily injections.

This paper develops a subcutaneous delivery platform for ultra-high-concentration protein therapeutics using a copolymer excipient, enabling reduced injection volumes and improved stability.

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

This paper develops polyacrylamide-based copolymers as broad-spectrum antibiotics effective against multiple pathogens and shows they can restore the efficacy of existing antibiotics.