Author

Leslee T. Nguyen

Stanford UniversityORCID 0000-0002-6750-4575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:mouse· 2 Organism:rat· 2 Assay:protein structure· 1

Frequent Co-Authors

Eric Andrew AppeliD· 4 shared Noah EckmaniD· 4 shared Andrea I. d’AquinoiD· 3 shared Carolyn K. JonsiD· 3 shared Changxin DongiD· 3 shared Christian M. WilliamsiD· 3 shared Jerry YaniD· 3 shared Olivia M. SaouafiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBioengineering

Eric Andrew AppelORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure-Property-Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery

Changxin Dong, Andrea I. d’Aquino, Samya Sen, Alakesh Alakesh, Carolyn K. Jons, Noah Eckman, Christian M. Williams, Leslee T. Nguyen, Jerry Yan, Olivia M. Saouaf, Ye Eun Song, Ian A. Hall, Katie Lu, Manoj K. Manna, Sara Kapasi, , Eric Andrew Appel

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

bioRxiv · May 18, 2026 · PreprintBioengineering

Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight

Andrea I. d’Aquino, Changxin Dong, Leslee T. Nguyen, Jerry Yan, Carolyn K. Jons, Olivia M. Saouaf, Ye Eun Song, Noah Eckman, Sara Kapasi, Christian M. Williams, Vanessa M. Doulames, Samya Sen, Manoj K. Manna, Alakesh Alakesh, Katie Lu, , Eric Andrew Appel

This paper develops long-acting hydrogel-based depot formulations of semaglutide and tirzepatide that maintain drug levels for over 6 weeks in a rat model, showing similar efficacy to daily injections.

Advanced Therapeutics · Feb 1, 2026Peer-reviewedBioengineering

Engineering Sustained-Release Broadly Neutralizing Antibody Formulations

Carolyn K. Jons, Catherine M. Kasse, Bryan T. Mayer, Ollivier Hyrien, Samya Sen, Emily L. Meany, Andrea I. d’Aquino, Priya Ganesh, Noah Eckman, Changxin Dong, Jerry Yan, Leslee T. Nguyen, Vanessa M. Doulames, Ye Eun Song, Olivia M. Saouaf, , Eric Andrew Appel

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

bioRxiv · May 27, 2025 · PreprintBioengineering

Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals

Alexander N. Prossnitz, Leslee T. Nguyen, Noah Eckman, Suraj Borkar, Samantha Tetef, Anton A. A. Autzen, Gerald G. Fuller, Eric Andrew Appel

The paper designs ultra-stable biopharmaceutical excipients by analyzing structure-function relationships of amphiphilic polymers, significantly improving insulin stability.

Advanced Science · Jan 7, 2025Peer-reviewedBioengineering