Shoshana C. Williams

Cross-Molecular Active Learning for the Discovery of Antimicrobial Polyacrylamides

This paper develops antimicrobial polyacrylamides using a cross-molecular machine learning pipeline trained on antimicrobial peptides, showing synergy with clinical drugs against E. coli biofilms.

Preventing peritendinous adhesions using lubricious supramolecular hydrogels

This paper develops lubricious supramolecular hydrogels to prevent peritendinous adhesions, showing improved recovery and safety in preclinical models.

Intranasal sertraline for the investigation of nose-to-brain delivery to mitigate systemic exposure

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

Engineering Sustained-Release Broadly Neutralizing Antibody Formulations

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

Polyacrylamide-based Antimicrobial Copolymers to Replace or Rescue Antibiotics

This paper develops polyacrylamide-based copolymers as broad-spectrum antibiotics effective against multiple pathogens and shows they can restore the efficacy of existing antibiotics.

The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging

The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.