Giorgio Lagna

This study shows that PKR-mediated integrated stress response drives PVOD pathogenesis in mice, with PKR knockout preventing vascular remodeling and pulmonary hypertension.

This study shows that older rats develop more severe PVOD after MMC treatment due to reduced protein phosphatase 1, leading to prolonged ISR activation, and that blocking the PKR-ISR pathway reduces PVOD symptoms.

This study shows that the amino-terminal region of Drosha is essential for pri-miRNA processing and ribosomal protein biogenesis, with Ago2 compensating for Drosha's absence in processing the miR-183 cluster.

The paper shows the Microprocessor complex regulates ribosomal protein synthesis by binding TOP motifs and promoting transcription elongation, linking ribosome biogenesis to cell growth.

The paper identifies a tissue-specific isomiR, miR-125b+A, which enhances cell survival by more potently inhibiting CASP6 expression in vascular smooth muscle cells.