Author

Brian B. Graham

San Francisco General HospitalORCID 0000-0001-7541-2585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Akiko HataiD· 2 shared Amit PrabhakariD· 2 shared Giorgio LagnaiD· 2 shared Meetu Wadhwa· 2 shared Prajakta Ghatpande· 2 shared Abhilash BarpandaiD· 1 shared Ananyaa Arvind· 1 shared Arun P. WiitaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Akiko HataORCID

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2 papers

Recent·Most cited

Cell BiologyJCI InsightPeer-reviewedAug 21, 2025

Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive Disease

Amit Prabhakar, Rahul Kumar, Meetu Wadhwa…·Akiko Hata

This study shows that PKR-mediated integrated stress response drives PVOD pathogenesis in mice, with PKR knockout preventing vascular remodeling and pulmonary hypertension.

3 citations

mouseproteomics

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Cell BiologybioRxivPreprintApr 16, 2024

Depletion of Protein Phosphatase 1 Results in Persistent Activation of the Integrated Stress Response and Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease

Amit Prabhakar, Meetu Wadhwa, Prajakta Ghatpande…·Akiko Hata

This study shows that older rats develop more severe PVOD after MMC treatment due to reduced protein phosphatase 1, leading to prolonged ISR activation, and that blocking the PKR-ISR pathway reduces PVOD symptoms.

DOI 10.1101/2024.04.16.589837

ratexperimental assay

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