Amit Prabhakar

Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive Disease

This study shows that PKR-mediated integrated stress response drives PVOD pathogenesis in mice, with PKR knockout preventing vascular remodeling and pulmonary hypertension.

Depletion of Protein Phosphatase 1 Results in Persistent Activation of the Integrated Stress Response and Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease

This study shows that older rats develop more severe PVOD after MMC treatment due to reduced protein phosphatase 1, leading to prolonged ISR activation, and that blocking the PKR-ISR pathway reduces PVOD symptoms.

Essential role of the amino-terminal region of Drosha for the Microprocessor function

This study shows that the amino-terminal region of Drosha is essential for pri-miRNA processing and ribosomal protein biogenesis, with Ago2 compensating for Drosha's absence in processing the miR-183 cluster.

Control of ribosomal protein synthesis by Microprocessor complex

The paper shows the Microprocessor complex regulates ribosomal protein synthesis by binding TOP motifs and promoting transcription elongation, linking ribosome biogenesis to cell growth.