Author

Meetu Wadhwa

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Akiko HataiD· 2 shared Amit PrabhakariD· 2 shared Brian B. GrahamiD· 2 shared Giorgio LagnaiD· 2 shared Prajakta Ghatpande· 2 shared Rahul KumariD· 2 shared Abhilash BarpandaiD· 1 shared Ananyaa Arvind· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Akiko HataORCID

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2 papers

Recent·Most cited

Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive Disease

Amit Prabhakar, Rahul Kumar, Meetu Wadhwa, Abhilash Barpanda, Joseph M. Lyons, Asavari Gowda, Simren Gupta, Ananyaa Arvind, Prajakta Ghatpande, Arun P. Wiita, Brian B. Graham, Giorgio Lagna, Akiko Hata

This study shows that PKR-mediated integrated stress response drives PVOD pathogenesis in mice, with PKR knockout preventing vascular remodeling and pulmonary hypertension.

JCI Insight · Aug 21, 2025Peer-reviewedCell Biology

Depletion of Protein Phosphatase 1 Results in Persistent Activation of the Integrated Stress Response and Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease

Amit Prabhakar, Meetu Wadhwa, Prajakta Ghatpande, Rahul Kumar, Brian B. Graham, Giorgio Lagna, Akiko Hata

This study shows that older rats develop more severe PVOD after MMC treatment due to reduced protein phosphatase 1, leading to prolonged ISR activation, and that blocking the PKR-ISR pathway reduces PVOD symptoms.

bioRxiv · Apr 16, 2024 · PreprintCell Biology