Sascha Hoppe

This study identifies gene expression adaptations of metastases to host tissue using single-cell RNA-sequencing and a novel computational approach, revealing liver-specific expression signatures in colorectal cancer metastases.

The paper uses single cell RNA-sequencing and genome-wide association study data to identify cell types and processes involved in Barrett's esophagus and esophageal adenocarcinoma risk.

The paper identifies a basal-like subtype in esophageal adenocarcinoma associated with relapse after chemoradiation and poor survival.