Marta Bódalo‐Torruella

RERE and the Mediator complex cooperate with EWSR1::FLI1 in the reprogramming of Translation and Alternative Splicing, the latter being a therapeutically targetable vulnerability in Ewing sarcoma

This paper identifies MED13L and RERE as genes regulated by EWSR1::FLI1 in Ewing sarcoma, showing their role in altering translation and alternative splicing, and demonstrates RBM39 inhibition as a therapeutic strategy.

EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma

This study shows that EWS-FLI1 expression in human embryonic mesenchymal stem cells leads to an ES-like transcriptome and tumor formation, despite not preferentially binding promoters.

Transcriptomics-Driven Machine Learning Models Accurately Predict Chemotherapy Response in Muscle-invasive Bladder Cancer

The paper develops a machine learning model using transcriptomic data to predict chemotherapy response in muscle-invasive bladder cancer with high accuracy.