Molecular BiologyPLoS GeneticsPeer-reviewed
Differential role of cytosolic Hsp70s in longevity assurance and protein quality control
Rebecca Andersson, Anna Maria Eisele-Bürger, Sarah Hanzén…·Thomas Nyström
The paper investigates the functional differences between Ssa4 and Ssa1/2 Hsp70s in yeast, showing Ssa4 can compensate for Ssa1/2 loss in some aspects of protein quality control but not all, and that Hsp104-dependent aggregate clearance is not essential for longevity.
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