Differential role of cytosolic Hsp70s in longevity assurance and protein quality control
Rebecca Andersson, Anna Maria Eisele-Bürger, Sarah Hanzén, Katarina Vielfort, David Öling, Frederik Eisele, Gustav Johansson, Hans Tobias Gustafsson, Kristian Kvint, Thomas Nyström
The paper investigates the functional differences between Ssa4 and Ssa1/2 Hsp70s in yeast, showing Ssa4 can compensate for Ssa1/2 loss in some aspects of protein quality control but not all, and that Hsp104-dependent aggregate clearance is not essential for longevity.
PLoS Genetics · Jan 11, 2021Peer-reviewedMolecular Biology