Frederik Eisele

This study develops molecular glue-like degraders that target TEM β-lactamases for degradation by DegP, showing improved synergy with piperacillin against resistant E. coli.

The paper evaluates the impact of PROTAC valency on hook effects, showing that trivalent PROTACs do not eliminate the hook effect but may alter its dynamics.

The paper investigates the functional differences between Ssa4 and Ssa1/2 Hsp70s in yeast, showing Ssa4 can compensate for Ssa1/2 loss in some aspects of protein quality control but not all, and that Hsp104-dependent aggregate clearance is not essential for longevity.