Shannon J. McKie

FLiPA quantitatively analyzes protein-glycosphingolipid interactions using fluorescent liposomes to study molecular determinants like cholesterol and membrane order.

This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.

The paper shows that altered sulfatide-binding by NF155 links glycosphingolipid imbalances to demyelination by affecting membrane protein abundance and axon-myelin contacts.