Janet Elwyn Deane

Development of py-mea-span for comprehensive analysis of multi-electrode array data and its application to LGI2-deficient neurons

Open-source Python package parses Axion spk files directly and matches NeuralMetric Tool outputs, then reveals burst and network burst hyperexcitability, without synchrony change, in LGI2-knockdown human iPSC neurons.

Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

South American Plasmodium falciparum isolates reveal new insights into the role of PfAAT1 in mediating resistance to Chloroquine

This study identifies region-specific PfAAT1 mutations in South American Plasmodium falciparum isolates that modulate chloroquine resistance through structural and functional analyses.

FLiPA: A versatile platform for quantitative analysis of protein-glycosphingolipid interactions

FLiPA quantitatively analyzes protein-glycosphingolipid interactions using fluorescent liposomes to study molecular determinants like cholesterol and membrane order.

Sialylated Gangliosides are Required for Plasma Membrane Organization and Neuronal Function

The paper shows that sialylated gangliosides are essential for plasma membrane organization and neuronal function, with ST3GAL5 deficiency causing severe disruptions in glycosphingolipid composition and neuronal activity.

Ensemble Machine Learning Approaches Predict Survival in Lower-Grade Glioma Based on Glycosphingolipid Gene Expression and Metabolic Modelling

The paper uses ensemble machine learning with GSL gene expression and metabolic models to predict survival in lower-grade glioma patients, identifying associations with cell motility and Wnt signaling.

Flexibility and modulation of translation initiation in enterovirus genomes

This study shows enteroviruses can use two upstream AUGs for translation initiation, with the second AUG providing a competitive advantage in specific host environments.

Optimisation of lytic herpes simplex virus infection in human induced pluripotent stem cell derived cortical neurones

This study optimizes HSV-1 infection in human iPSC-derived cortical neurones, enabling efficient and synchronous infection for microscopy and biochemical analysis.

Alphaherpesvirus pUL21 homologues use non-canonical motifs to compete with cellular adaptors for protein phosphatase 1 binding

This study identifies non-canonical TROPPO motifs in alphaherpesvirus proteins that compete with cellular adaptors for PP1 binding, revealing a novel mechanism of PP1 recruitment.

Conformational Dynamics and Membrane Insertion Mechanism of B4GALNT1 in Ganglioside Synthesis

This study reveals the conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis using crystal structures and molecular simulations.

Patching up the nucleus: a novel role for PMLII in nuclear envelope rupture repair

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

Plasma Membrane Remodelling in GM2 Gangliosidoses Drives Synaptic Dysfunction

This study develops i3Neuron models of Tay-Sachs and Sandhoff diseases, revealing plasma membrane remodeling and synaptic dysfunction due to GM2 ganglioside accumulation.

Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.

Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

The paper shows that altered sulfatide-binding by NF155 links glycosphingolipid imbalances to demyelination by affecting membrane protein abundance and axon-myelin contacts.

The mechanism of sphingolipid processing revealed by a GALC-SapA complex structure

The paper reveals the structure of the GALC-SapA complex, showing how it processes glycosphingolipids and explains saposin binding specificity.