The paper identifies altPIDD1 as the primary protein product of the PIDD1 gene, showing higher expression and cytoskeletal interactions compared to the known PIDD1 protein.

Life Science Alliance · Nov 12, 2024Peer-reviewedBiochemistry

Newfound coding potential of transcripts unveils missing members of human protein communities

Sébastien Leblanc, Marie A. Brunet, Jean‐François Jacques, Amina M. Lekehal, Andréa Duclos, Alexia Tremblay, Alexis Bruggeman-Gascon, Sondos Samandi, Mylène Brunelle, Alan Arthur Cohen, Michelle S. Scott, Xavier Roucou

The paper identifies 280 alternative proteins in human protein-protein interaction networks using proteogenomic data and experimental validation, revealing new interactions and functional roles.

Genomics Proteomics & Bioinformatics · Sep 30, 2022Peer-reviewedSystems Biology

FUS gene is dual-coding with both proteins united in FUS-mediated toxicity

Marie A. Brunet, Jean‐François Jacques, Sonya Nassari, Giulia E. Tyzack, Philip McGoldrick, Lorne H. Zinman, Steve Jean, Janice Robertson, Rickie Patani, Xavier Roucou

The paper identifies an alternative open reading frame (altORF) within the FUS gene that contributes to toxicity in neurodegenerative models.

bioRxiv · Apr 14, 2020 · PreprintGenetics