Sonya Nassari

NANOCUTSIGHT: A NANOPORE-SEQUENCING APPROACH AND ANALYSIS PIPELINE TO ASSESS GENOME EDITING EFFICACY IN VARIOUS CELL POPULATIONS

NanoCutSight is a nanopore sequencing pipeline to quantify indels and identify modification types in genome editing, benchmarked on guide RNAs in cell and organoid models.

A Proximity MAP of RAB GTPases

The paper uses proximity labeling to identify proteins interacting with 23 human RAB GTPases, revealing novel functional connections and interactions.

Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity

The paper shows that inhibiting autophagy in intestinal stem cells increases enteroendocrine cell differentiation via Stat92E activity in Drosophila.

CXCR7 promotes foetal myoblast fusion at muscle fiber tips independently of Myomaker via a beta1integrin-EGFR-dependent mechanism

The paper shows CXCR7 promotes myoblast fusion at muscle fiber tips in chicken embryos through a beta1integrin-EGFR pathway, independent of Myomaker.

BMP signalling directs a fibroblast-to-myoblast conversion at the connective tissue/muscle interface to pattern limb muscles

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.

FUS gene is dual-coding with both proteins united in FUS-mediated toxicity

The paper identifies an alternative open reading frame (altORF) within the FUS gene that contributes to toxicity in neurodegenerative models.

Genome-wide strategies identify molecular niches regulated by connective tissue-associated transcription factors

The paper identifies molecular niches regulated by connective tissue-associated transcription factors through RNA-seq and ChIP-seq in chick limb cells.

In addition to being a marker for muscle connective tissue, Odd skipped-related 2 (OSR2) is expressed in differentiated muscle cells during chick development