Author

David R. Graykowski

UK Dementia Research InstituteORCID 0000-0002-8004-2811Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Morgan ShengiD· 2 shared Amy DeikiD· 1 shared Binhui ZhaoiD· 1 shared Borislav DejanoviciD· 1 shared Bryan J. SongiD· 1 shared Carlo Sala FrigerioiD· 1 shared Charles ArberiD· 1 shared Clary B. ClishiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Morgan ShengORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 25, 2025

Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder

Xiao‐Man Liu, Horia Pribiag, Deeksha Misri…·Morgan Sheng

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

6 citations

mouseproteomics

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NeurosciencePLoS BiologyPeer-reviewedJul 23, 2024

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's Disease

Rikesh M. Rajani, Robert A. Ellingford, Mariam Hellmuth…·Marc Aurel Busche

This study shows that oligodendrocytes produce amyloid beta in Alzheimer's Disease and that suppressing this production improves brain pathology and neuronal function.

60 citationstop 1%

mouseexperimental assay

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NeuroscienceScience Translational MedicinePeer-reviewedMar 29, 2023

Neuronal pentraxin Nptx2 regulates complement activity in the brain

Jiechao Zhou, Sarah D. Wade, David R. Graykowski…·Borislav Dejanovic

This study identifies Nptx2 as a regulator of complement activity in the brain, showing its role in preventing microglial synapse elimination in health and disease.

152 citationstop 1%

mousehuman

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